How the brain functions with NAD+
How NAD+ Changes in the Brain as We Age – And How NAD+ Therapy Can Help
Understanding brain aging and the powerful role of NAD+
Introduction: What Happens to the Brain as We Age?
As we grow older, many people notice changes like tiredness, forgetfulness, low mood, or disrupted sleep. But what causes these shifts?
A key part of the answer lies in a molecule called NAD+. NAD+ is found in every cell in your body and helps turn nutrients into energy. It’s also involved in keeping your brain sharp, your cells healthy, and your body resilient.
But here’s the challenge:
NAD+ levels naturally drop with age
This decline can affect the brain, especially in areas that manage stress, memory, metabolism, and even how we feel
A new study has now given us a closer look at what’s really happening — and how NAD+ injections or supplementation might help restore balance and protect brain health.
What Is NAD+ and Why Does It Matter?
Let’s keep it simple. NAD+ helps your body:
Create energy from food
Repair cells and protect against damage
Keep the brain and nervous system healthy
Support healthy aging and mood balance
When NAD+ levels drop (which they do with age), you might feel:
Low energy
Poor concentration
Emotional changes (anxiety or low mood)
Slower recovery or sleep issues
This is why NAD+ therapy is becoming a popular option for people seeking natural ways to boost energy, mental clarity, and long-term wellness.
What the New Study Found About NAD+ and the Brain
Researchers looked closely at how NAD+ changes in a part of the brain called the hypothalamus, which helps regulate:
Aging
Sleep and wake cycles
Hormone balance
Appetite and metabolism
Using new tools, they were able to measure NAD+ in small sections of the hypothalamus in young and older mice.
Here’s what they discovered:
NAD+ drops with age — but only in some areas
In older mice, NAD+ levels went down in parts like the arcuate nucleus (ARC), ventromedial hypothalamus (VMH), and lateral hypothalamus (LH)
But in another area — the dorsomedial hypothalamus (DMH) — NAD+ levels stayed steady, even in old age.
What this means for humans:
While more research is needed, this study shows that declining NAD+ in the brain can play a role in how we age, especially when it comes to energy, sleep, and hormone control. Boosting NAD+ levels through therapy will help support healthy brain function and slow age-related changes. It’s a promising step toward understanding how NAD+ affects our health as we get older.
NAD+ can be restored with natural boosters
A supplement called NMN (nicotinamide mononucleotide) increased NAD+ levels across all areas of the brain
Another approach, using eNampt-EVs (small particles taken from young mice), raised NAD+ in specific areas like the ARC and DMH
This shows that different parts of the brain age differently — and that NAD+ can be boosted with the right support.
What Does This Mean for You?
This study tells us three important things:
NAD+ is essential for brain health, especially as we age
Not all brain areas age the same — some are more sensitive to NAD+ loss than others
You can support your NAD+ levels with therapy like NAD+ injections or NMN supplements
At Total Therapy London, we specialise in safe, science-backed NAD+ therapy. Whether you want more energy, sharper focus, or support for long-term brain wellness, NAD+ may be part of your solution.
Who Can Benefit from NAD+ Therapy?
You may benefit from NAD+ injections if you:
Feel tired even after rest
Struggle with memory or brain fog
Experience stress, mood swings, or poor sleep
Want to support healthy aging from the inside out
How NAD+ Injections Work at Total Therapy London
A quick, safe injection into the muscle
Works fast — many clients feel better within hours or days
Supports cell energy, brain clarity, and mood regulation
Done under professional care in a calming, clinical setting
Our team is here to guide you, answer questions, and create a plan that fits your lifestyle.
Conclusion: Small Changes, Big Results
Aging is natural — but how we support our bodies can make a big difference.
This new research shows that keeping NAD+ levels strong in the brain may be key to staying sharp, calm, and full of energy as we age.
If you’re curious about NAD+ therapy, we’re here to help.
Call to Action
Have you tried NAD+ therapy or felt signs of brain fatigue? Let us know in the comments — your story may help others!
Want personalised support? Contact our clinic to book a consultation or ask questions.
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